| 1 | 2021 | Bahreïn | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 1 | |
| 2021 | Bahreïn | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 2 | 2021 | Émilie-Romagne | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 2 | |
| 2021 | Émilie-Romagne | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 8 | ab | Accrochage |
| 3 | 2021 | Portugal | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 1 | |
| 2021 | Portugal | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 3 | |
| 4 | 2021 | Espagne | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 1 | |
| 2021 | Espagne | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 5 | 2021 | Monaco | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 7 | 7 | |
| 2021 | Monaco | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | ab | Ecrou de roue |
| 6 | 2021 | Azerbaïdjan | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 15 | |
| 2021 | Azerbaïdjan | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 10 | 12 | |
| 7 | 2021 | France | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | France | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 4 | |
| 8 | 2021 | Styrie | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Styrie | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 5 | 3 | |
| 9 | 2021 | Autriche | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 4 | 4 | |
| 2021 | Autriche | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 5 | 2 | |
| 10 | 2021 | Grande-Bretagne | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 1 | |
| 2021 | Grande-Bretagne | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 11 | 2021 | Hongrie | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 2 | |
| 2021 | Hongrie | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 2 | ab | Carambolage |
| 12 | 2021 | Belgique | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 2021 | Belgique | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 12 | |
| 13 | 2021 | Pays-Bas | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Pays-Bas | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 14 | 2021 | Italie | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 4 | ab | Accrochage |
| 2021 | Italie | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 19 | 3 | |
| 15 | 2021 | Russie | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 4 | 1 | |
| 2021 | Russie | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 5 | |
| 16 | 2021 | Turquie | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 11 | 5 | |
| 2021 | Turquie | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 1 | |
| 17 | 2021 | Etats-Unis | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Etats-Unis | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 9 | 6 | |
| 18 | 2021 | Mexico City | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Mexico City | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 15 | |
| 19 | 2021 | São Paulo | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 10 | 1 | |
| 2021 | São Paulo | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 3 | |
| 20 | 2021 | Qatar | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 1 | |
| 2021 | Qatar | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 6 | ab | Dégâts |
| 21 | 2021 | Arabie saoudite | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 1 | |
| 2021 | Arabie saoudite | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 3 | |
| 22 | 2021 | Abou Dhabi | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Abou Dhabi | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 6 | 6 | |