| 1 | 2021 | Baréin | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 18 | Turbo |
| 2021 | Baréin | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 14 | |
| 2 | 2021 | Emilia-Romaña | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 14 | ab | Accidente |
| 2021 | Emilia-Romaña | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 12 | ab | Enganche |
| 3 | 2021 | Portugal | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 18 | |
| 2021 | Portugal | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 11 | 16 | |
| 4 | 2021 | España | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 19 | 16 | |
| 2021 | España | Williams Racing | 45 | NISSANY Roy | Mercedes M12 E Performance V6 t h | Pirelli | | t | Tercer piloto |
| 2021 | España | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 14 | |
| 5 | 2021 | Mónaco | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 15 | |
| 2021 | Mónaco | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 14 | |
| 6 | 2021 | Azerbaiyán | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 16 | |
| 2021 | Azerbaiyán | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 17 | Caja de cambios |
| 7 | 2021 | Francia | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 18 | |
| 2021 | Francia | Williams Racing | 45 | NISSANY Roy | Mercedes M12 E Performance V6 t h | Pirelli | | t | Tercer piloto |
| 2021 | Francia | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 14 | 12 | |
| 8 | 2021 | Estiria | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 17 | |
| 2021 | Estiria | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 10 | ab | Presión aire |
| 9 | 2021 | Austria | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 16 | |
| 2021 | Austria | Williams Racing | 45 | NISSANY Roy | Mercedes M12 E Performance V6 t h | Pirelli | | t | Tercer piloto |
| 2021 | Austria | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 8 | 11 | |
| 10 | 2021 | Gran Bretaña | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 14 | |
| 2021 | Gran Bretaña | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 12 | 12 | |
| 11 | 2021 | Hungría | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 7 | |
| 2021 | Hungría | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 8 | |
| 12 | 2021 | Bélgica | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 10 | 9 | |
| 2021 | Bélgica | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 13 | 2021 | Países Bajos | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 19 | 16 | |
| 2021 | Países Bajos | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 11 | 17 | Caja de cambios |
| 14 | 2021 | Italia | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 11 | |
| 2021 | Italia | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 14 | 9 | |
| 15 | 2021 | Rusia | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 19 | Daños por colisión |
| 2021 | Rusia | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 10 | |
| 16 | 2021 | Turquía | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 17 | |
| 2021 | Turquía | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 15 | |
| 17 | 2021 | Estados Unidos | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 14 | 15 | |
| 2021 | Estados Unidos | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 20 | 14 | |
| 18 | 2021 | Ciudad de México | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 17 | |
| 2021 | Ciudad de México | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 16 | |
| 19 | 2021 | São Paulo | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 16 | |
| 2021 | São Paulo | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 13 | |
| 20 | 2021 | Catar | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 17 | ab | Pinchazo |
| 2021 | Catar | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 17 | |
| 21 | 2021 | Arabia Saudita | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 12 | |
| 2021 | Arabia Saudita | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 14 | ab | Enganche |
| 22 | 2021 | Abu Dabi | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | ab | Accidente |
| 2021 | Abu Dabi | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 17 | ab | Caja de cambios |
| 2021 | Abu Dabi | Williams Racing | 89 | AITKEN Jack | Mercedes M12 E Performance V6 t h | Pirelli | | t | Tercer piloto |