| 1 | 2021 | Bahrain | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 18 | Turbo |
| 2021 | Bahrain | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 14 | |
| 2 | 2021 | Emilia-Romagna | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 14 | ab | Accident |
| 2021 | Emilia-Romagna | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 12 | ab | Collision |
| 3 | 2021 | Portugal | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 18 | |
| 2021 | Portugal | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 11 | 16 | |
| 4 | 2021 | Spain | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 19 | 16 | |
| 2021 | Spain | Williams Racing | 45 | NISSANY Roy | Mercedes M12 E Performance V6 t h | Pirelli | | t | Third driver |
| 2021 | Spain | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 14 | |
| 5 | 2021 | Monaco | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 15 | |
| 2021 | Monaco | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 14 | |
| 6 | 2021 | Azerbaijan | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 16 | |
| 2021 | Azerbaijan | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 17 | Gearbox |
| 7 | 2021 | France | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 18 | |
| 2021 | France | Williams Racing | 45 | NISSANY Roy | Mercedes M12 E Performance V6 t h | Pirelli | | t | Third driver |
| 2021 | France | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 14 | 12 | |
| 8 | 2021 | Styria | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 17 | |
| 2021 | Styria | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 10 | ab | Air pressure |
| 9 | 2021 | Austria | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 16 | |
| 2021 | Austria | Williams Racing | 45 | NISSANY Roy | Mercedes M12 E Performance V6 t h | Pirelli | | t | Third driver |
| 2021 | Austria | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 8 | 11 | |
| 10 | 2021 | Britain | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 14 | |
| 2021 | Britain | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 12 | 12 | |
| 11 | 2021 | Hungary | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 7 | |
| 2021 | Hungary | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 8 | |
| 12 | 2021 | Belgium | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 10 | 9 | |
| 2021 | Belgium | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 13 | 2021 | Netherlands | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 19 | 16 | |
| 2021 | Netherlands | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 11 | 17 | Gearbox |
| 14 | 2021 | Italy | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 11 | |
| 2021 | Italy | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 14 | 9 | |
| 15 | 2021 | Russia | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 18 | 19 | Collision damage |
| 2021 | Russia | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 10 | |
| 16 | 2021 | Turkey | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 17 | |
| 2021 | Turkey | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 15 | |
| 17 | 2021 | USA | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 14 | 15 | |
| 2021 | USA | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 20 | 14 | |
| 18 | 2021 | Mexico City | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 17 | |
| 2021 | Mexico City | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 16 | |
| 19 | 2021 | São Paulo | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 16 | |
| 2021 | São Paulo | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 17 | 13 | |
| 20 | 2021 | Qatar | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 17 | ab | Puncture |
| 2021 | Qatar | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 15 | 17 | |
| 21 | 2021 | Saudi Arabia | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 12 | |
| 2021 | Saudi Arabia | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 14 | ab | Collision |
| 22 | 2021 | Abu Dhabi | Williams Racing | 6 | LATIFI Nicholas | Mercedes M12 E Performance V6 t h | Pirelli | 16 | ab | Accident |
| 2021 | Abu Dhabi | Williams Racing | 63 | RUSSELL George | Mercedes M12 E Performance V6 t h | Pirelli | 17 | ab | Gearbox |
| 2021 | Abu Dhabi | Williams Racing | 89 | AITKEN Jack | Mercedes M12 E Performance V6 t h | Pirelli | | t | Third driver |