| 1 | 2021 | Bahrain | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 1 | |
| 2021 | Bahrain | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 2 | 2021 | Emilia-Romagna | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 2 | |
| 2021 | Emilia-Romagna | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 8 | ab | Collision |
| 3 | 2021 | Portugal | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 1 | |
| 2021 | Portugal | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 3 | |
| 4 | 2021 | Spain | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 1 | |
| 2021 | Spain | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 5 | 2021 | Monaco | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 7 | 7 | |
| 2021 | Monaco | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | ab | Wheel nut |
| 6 | 2021 | Azerbaijan | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 15 | |
| 2021 | Azerbaijan | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 10 | 12 | |
| 7 | 2021 | France | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | France | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 4 | |
| 8 | 2021 | Styria | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Styria | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 5 | 3 | |
| 9 | 2021 | Austria | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 4 | 4 | |
| 2021 | Austria | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 5 | 2 | |
| 10 | 2021 | Britain | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 1 | |
| 2021 | Britain | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 11 | 2021 | Hungary | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 2 | |
| 2021 | Hungary | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 2 | ab | Pile-up |
| 12 | 2021 | Belgium | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 2021 | Belgium | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 13 | 12 | |
| 13 | 2021 | Netherlands | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 2 | 2 | |
| 2021 | Netherlands | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 3 | 3 | |
| 14 | 2021 | Italy | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 4 | ab | Collision |
| 2021 | Italy | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 19 | 3 | |
| 15 | 2021 | Russia | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 4 | 1 | |
| 2021 | Russia | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 16 | 5 | |
| 16 | 2021 | Turkey | Mercedes AMG Petronas F1 Team | 44 | HAMILTON Lewis | Mercedes M12 E Performance V6 t h | Pirelli | 11 | 5 | |
| 2021 | Turkey | Mercedes AMG Petronas F1 Team | 77 | BOTTAS Valtteri | Mercedes M12 E Performance V6 t h | Pirelli | 1 | 1 | |